Biologically-inspired transport of solid spherical nanoparticles in an electrically-conducting viscoelastic fluid with heat transfer

Bio-inspired pumping systems exploit a variety of mechanisms including peristalsis to achieve more efficient propulsion. Non-conducting, uniformly dispersed, spherical nano-sized solid particles suspended in viscoelastic medium forms a complex working matrix. Electromagnetic pumping systems often employ complex working fluids. A simulation of combined electromagnetic bio-inspired propulsion is observed in the present article. Currents formation has increasingly more applications in mechanical and medical industries. A mathematical study is conducted for magnetohydrodynamic pumping of a bi-phase nanofluid coupled with heat transfer in a planar channel. Two-phase model is employed to separately identity the effects of solid nanoparticles. Base fluid employs Jeffery’s model to address viscoelastic characteristics. The model is simplified using of long wavelength and creeping flow approximations. The formulation is taken to wave frame and non-dimensionalize the equations. The resulting boundary value problem is solved analytically, and exact expressions are derived for the fluid velocity, particulate velocity, fluid/particle temperature, fluid and particulate volumetric flow rates, axial pressure gradient and pressure rise. The influence of volume fraction density, Prandtl number, Hartmann number, Eckert number and relaxation time on flow and thermal characteristics is evaluated in detail. The axial flow is accelerated with increasing relaxation time and greater volume fraction whereas it is decelerated with greater Hartmann number. Both fluid and particulate temperature are increased with increment in Eckert and Prandtl number whereas it is reduced when the volume fraction density increases. With increasing Hartmann, number pressure rise is reduced. Furthermore, pressure is reduced with greater relaxation time in the retrograde pumping region whereas it is elevated in the co-pumping and free pumping regions. The number of the trapped boluses is decreased whereas the quantity of boluses increases with a rise in volume fraction density of particles

Computational framework of magnetized MgO-Ni/water based stagnation nanoflow past an elastic stretching surface : application in solar energy coatings

In this article, motivated by novel nanofluid solar energy coating systems, a mathematical model of hybrid Magnesium oxide (MgO)-nickel (Ni) nanofluid magnetohydrodynamic (MHD) stagnation point flow impinging on a porous elastic stretching surface in a porous medium is developed. The hybrid nanofluid is electrically conducting and magnetic Reynolds number is sufficiently large to invoke induced magnetic field. A Darcy model is adopted for the isotropic, homogenous porous medium. The boundary conditions account for the impacts of velocity slip and thermal slip. Heat generation (source)/absorption (sink) and also viscous dissipation effects are included. The mathematical formulation has been performed with the help of similarity variables and the resulting coupled nonlinear dimensionless ordinary differential equations have been solved numerically with the help of shooting method. To test the validity of the current results and the convergence of the solutions, a numerical comparison with previously published results is included. Numerical results are plotted for the effect of emerging parameters on velocity, temperature, magnetic induction, skin friction and Nusselt number. With increment in nanoparticle volume fraction of both MgO and Ni nanoparticles, the temperature and thermal boundary layer thickness of the nanofluid are elevated. An increase in porous medium parameter (Darcy number), velocity slip and thermal Grashof number all enhance the induced magnetic field. Initially increment in nanoparticle volume fraction for both MgO and Ni suppress the magnetic induction near the wall although subsequently further from the wall this effect is reversed. Temperature is enhanced with heat generation whereas it is depleted with heat absorption and thermal slip effects. Overall excellent thermal enhancement is achieved by the hybrid nanofluid

Differential transform solution for hall and ion slip effects on radiative-convective casson flow from a stretching sheet with convective heating

Magnetohydrodynamic (MHD) materials processing is becoming increasingly popular in the 21st century since it offers significant advantages over conventional systems including improved manipulation of working fluids, reduction in wear and enhanced sustainability. Motivated by these developments, the present work develops a mathematical model for Hall and Ion slip effects on non-Newtonian Casson fluid dynamics and heat transfer towards a stretching sheet with a convective heating boundary condition under a transverse magnetic field. The governing conservation equations for mass, linear momentum and thermal (energy) are simplified with the aid of similarity variables and Ohm’s law. The emerging nonlinear coupled ordinary differential equations are solved with an analytical technique known as the differential transform method (DTM). The impact of different emerging parameters is presented and discussed with the help of graphs and tables. Generally aqueous electro-conductive polymers are considered for which a Prandtl number of 6.2 is employed. With increasing Hall parameter and ion slip parameter the flow is accelerated whereas it is decelerated with greater magnetic parameter and rheological (Casson) fluid parameter. Skin friction is also decreased with greater magnetic field effect whereas it is increased with stronger Hall parameter and ion slip parameter values

Numerical study of radiative Maxwell viscoelastic magnetized flow from a stretching permeable sheet with the Cattaneo–Christov heat flux model

In this article, the Cattaneo-Christov heat flux model is implemented to study non-Fourier heat and mass transfer in the magnetohydrodynamic (MHD) flow of an upper convected Maxwell (UCM) fluid over a permeable stretching sheet under a transverse constant magnetic field. Thermal radiation and chemical reaction effects are also considered. The nonlinear partial differential conservation equations for mass, momentum, energy and species conservation are transformed with appropriate similarity variables into a system of coupled, highly nonlinear ordinary differential equations with appropriate boundary conditions. Numerical solutions have been presented for the influence of elasticity parameter (), magnetic parameter (M2), suction/injection parameter (λ), Prandtl number (Pr), conduction-radiation parameter (Rd), sheet stretching parameter (A), Schmidt number (Sc), chemical reaction parameter (γ_c), modified Deborah number with respect to relaxation time of heat flux (i.e. non-Fourier Deborah number) on velocity components, temperature and concentration profiles using the successive Taylor series linearization method (STSLM) utilizing Chebyshev interpolating polynomials and Gauss-Lobatto collocation. The effects of selected parameters on skin friction coefficient, Nusselt number and Sherwood number are also presented with the help of tables. Verification of the STSLM solutions is achieved with existing published results demonstrating close agreement. Further validation of skin friction coefficient, Nusselt number and Sherwood number values computed with STSLM is included using Mathematica software shooting quadrature

Slip and hall current effects on Jeffrey fluid suspension flow in a peristaltic hydromagnetic blood micropump

The magnetic properties of blood allow it to be manipulated with an electromagnetic field. Electromagnetic blood flow pumps are a robust technology which provide more elegant and sustainable performance compared with conventional medical pumps. Blood is a complex multi-phase suspension with non-Newtonian characteristics which are significant in micro-scale transport. Motivated by such applications, in the present article a mathematical model is developed for magnetohydrodynamic (MHD) pumping of blood in a deformable channel with peristaltic waves. A Jeffery’s viscoelastic formulation is employed for the rheology of blood. A twophase fluid-particle (“dusty”) model is utilized to better simulate suspension characteristics (plasma and erythrocytes). Hall current and wall slip effects are incorporated to achieve more realistic representation of actual systems. A two-dimensional asymmetric channel with dissimilar peristaltic wave trains propagating along the walls is considered. The governing conservation equations for mass, fluid and particle momentum are formulated with appropriate boundary conditions. The model is simplified using of long wavelength and creeping flow approximations. The model is also transformed from the fixed frame to the wave frame and rendered non-dimensional. Analytical solutions are derived. The resulting boundary value problem is solved analytically and exact expressions are derived for the fluid velocity, particulate velocity, fluid/particle fluid and particulate volumetric flow rates, axial pressure gradient, pressure rise and skin friction distributions are evaluated in detail. Increasing Hall current parameter reduces bolus growth in the channel, particle phase velocity and pressure difference in the augmented pumping region whereas it increases fluid phase velocity, axial pressure gradient and pressure difference in the pumping region. Increasing the hydrodynamic slip parameter accelerates both particulate and fluid phase flow at and close to the channel walls, enhances wall skin friction, boosts pressure difference in the augmented pumping region and increases bolus magnitudes. Increasing viscoelastic parameter (stress relaxation time to retardation time ratio) decelerates the fluid phase flow, accelerates the particle phase flow, decreases axial pressure gradient, elevates pressure difference in the augmented pumping region and reduces pressure difference in the pumping region. Increasing drag particulate suspension parameter decelerates the particle phase velocity, accelerates the fluid phase velocity, strongly elevates axial pressure gradient and reduces pressure difference (across one wavelength) in the augmented pumping region. Increasing particulate volume fraction density enhances bolus magnitudes in both the upper and lower zones of the channel and elevates pressure rise in the augmented pumping region

Numerical study of slip and radiative effects on magnetic Fe3O4-water-based nanofluid flow from a nonlinear stretching sheet in porous media with Soret and Dufour diffusion

Increasingly sophisticated techniques are being developed for the manufacture of functional nanomaterials. A growing interest is also developing in magnetic nanofluid coatings which contain magnetite nanoparticles suspended in a base fluid and are responsive to external magnetic fields. These nanomaterials are “smart” and their synthesis features high-temperature environments in which radiative heat transfer is present. Diffusion processes in the extruded nanomaterial sheet also feature Soret and Dufour (cross) diffusion effects. Filtration media are also utilized to control the heat, mass and momentum characteristics of extruded nanomaterials and porous media impedance effects arise. Magnetite nanofluids have also been shown to exhibit hydrodynamic wall slip which can arise due to non-adherence of the nanofluid to the boundary. Motivated by the multi-physical nature of magnetic nanomaterial manufacturing transport phenomena, in this paper, we develop a mathematical model to analyze the collective influence of hydrodynamic slip, radiative heat flux and cross-diffusion effects on transport phenomena in ferric oxide (Fe3O4-water) magnetic nanofluid flow from a nonlinear stretching porous sheet in porous media. Hydrodynamic slip is included. Porous media drag is simulated with the Darcy model. Viscous magnetohydrodynamic theory is used to simulate Lorentzian magnetic drag effects. The Rosseland diffusion flux model is employed for thermal radiative effects. A set of appropriate similarity transformation variables are deployed to convert the original partial differential boundary value problem into an ordinary differential boundary value problem. The numerical solution of the coupled, multi-degree, nonlinear problem is achieved with an efficient shooting technique in MATLAB symbolic software. The physical influences of Hartmann (magnetic) number, Prandtl number, Richardson number, Soret (thermo-diffusive) number, permeability parameter, concentration buoyancy ratio, radiation parameter, Dufour (diffuso-thermal) parameter, momentum slip parameter and Schmidt number on transport characteristics (e.g. velocity, nanoparticle concentration and temperature profiles) are investigated, visualized and presented graphically. Flow deceleration is induced with increasing Hartmann number and wall slip, whereas flow acceleration is generated with greater Richardson number and buoyancy ratio parameter. Temperatures are elevated with increasing Dufour number and radiative parameter. Concentration magnitudes are enhanced with Soret number, whereas they are depleted with greater Schmidt number. Validation of the MATLAB computations with special cases of the general model is included. Further validation with generalized differential quadrature (GDQ) is also included

Blood spots as an alternative to whole blood collection and the effect of a small monetary incentive to increase participation in genetic association studies

<p>Abstract</p> <p>Background</p> <p>Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting peripheral blood samples from which analytes in addition to DNA can be obtained.</p> <p>Methods</p> <p>To determine if offering blood spot collection would increase participation in genetic epidemiologic studies, we conducted a study of collecting dried blood spot cards by mail from a sample of female cancer cases (n = 134) and controls (n = 256) who were previously selected for a breast cancer genetics study and declined to provide a venipuncture blood sample. Participants were also randomized to receive either a $2.00 bill or no incentive with the blood spot collection kits.</p> <p>Results</p> <p>The average time between the venipuncture sample refusal and recruitment for the blood spot collection was 4.4 years. Thirty-seven percent of cases and 28$2.00 incentive vs. 26% for no incentive, p = 0.6), it was significantly associated with participation among the breast cancer cases (48% vs. 27%, respectively, p = 0.01). There did not appear to be any bias in response since no differences between cases and controls and incentive groups were observed when examining several demographic, work history and radiation exposure variables.</p> <p>Conclusion</p> <p>This study demonstrates that collection of dried blood spot cards in addition to venipuncture blood samples may be a feasible method to increase participation in genetic case-control studies.</p

Theoretical study of Oldroyd-b visco-elastic fluid flow through curved pipes with slip effects in polymer flow processing

The characteristics of the flow field of both viscous and viscoelastic fluids passing through a curved pipe with a Navier slip boundary condition have been investigated analytically in the present study. The Oldroyd-B constitutive equation is employed to simulate realistic transport of dilute polymeric solutions in curved channels. In order to linearize the momentum and constitutive equations, a perturbation method is used in which the ratio of radius of cross section to the radius of channel curvature is employed as the perturbation parameter. The intensity of secondary and main flows is mainly affected by the hoop stress and it is demonstrated in the present study that both the Weissenberg number (the ratio of elastic force to viscous force) and slip coefficient play major roles in determining the strengths of both flows. It is also shown that as a result of an increment in slip coefficient, the position of maximum velocity markedly migrates away from the pipe center towards the outer side of curvature. Furthermore, results corresponding to Navier slip scenarios exhibit non-uniform distributions in both the main and lateral components of velocity near the wall which can notably vary from the inner side of curvature to the outer side. The present solution is also important in polymeric flow processing systems because of experimental evidence indicating that the no-slip condition can fail for these flows, which is of relevance to chemical engineers

Toxoplasma gondii Lysine Acetyltransferase GCN5-A Functions in the Cellular Response to Alkaline Stress and Expression of Cyst Genes

Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in response to stresses that prompt development into latent bradyzoite cysts. We have previously linked histone acetylation with the expression of stage-specific genes, but the factors involved remain to be determined. We sought to determine if GCN5, which operates as a transcriptional co-activator by virtue of its histone acetyltransferase (HAT) activity, contributed to stress-induced changes in gene expression in Toxoplasma. In contrast to other lower eukaryotes, Toxoplasma has duplicated its GCN5 lysine acetyltransferase (KAT). Disruption of the gene encoding for TgGCN5-A in type I RH strain did not produce a severe phenotype under normal culture conditions, but here we show that the TgGCN5-A null mutant is deficient in responding to alkaline pH, a common stress used to induce bradyzoite differentiation in vitro. We performed a genome-wide analysis of the Toxoplasma transcriptional response to alkaline pH stress, finding that parasites deleted for TgGCN5-A fail to up-regulate 74% of the stress response genes that are induced 2-fold or more in wild-type. Using chromatin immunoprecipitation, we verify an enrichment of TgGCN5-A at the upstream regions of genes activated by alkaline pH exposure. The TgGCN5-A knockout is also incapable of up-regulating key marker genes expressed during development of the latent cyst form, and is impaired in its ability to recover from alkaline stress. Complementation of the TgGCN5-A knockout restores the expression of these stress-induced genes and reverses the stress recovery defect. These results establish TgGCN5-A as a major contributor to the alkaline stress response in RH strain Toxoplasma

Effect of varying skin surface electrode position on electroretinogram responses recorded using a handheld stimulating and recording system

Purpose A handheld device (the RETeval system, LKC Technologies) aims to increase the ease of electroretinogram (ERG) recording by using specially designed skin electrodes, rather than corneal electrodes. We explored effects of electrode position on response parameters recorded using this device. Methods Healthy adult twins were recruited from the TwinsUK cohort and underwent recording of light-adapted flicker ERGs (corresponding to international standard stimuli). In Group 1, skin electrodes were placed in a “comfortable” position, which was up to 20 mm below the lid margin. For subsequent participants (Group 2), the electrode was positioned 2 mm from the lid margin as recommended by the manufacturer. Amplitudes and peak times (averaged from both eyes) were compared between groups after age-matching and inclusion of only one twin per pair. Light-adapted flicker and flash ERGs were recorded for an additional 10 healthy subjects in two consecutive recording sessions: in the test eye, electrode position was varied from 2 to 10–20 mm below the lid margin between sessions; in the fellow (control) eye, the electrode was 2 mm below the lid margin throughout. Amplitudes and peak times (test eye normalised to control eye) were compared for the two sessions. Results Including one twin per pair, and age-matching yielded 28 individuals per group. Flicker ERG amplitudes were significantly lower for Group 1 than Group 2 participants (p = 0.0024). However, mean peak times did not differ between groups (p = 0.54). For the subjects in whom electrode position was changed between recording sessions, flash and flicker amplitudes were significantly lower when positioned further from the lid margin (p  0.5). Conclusions Moving the skin electrodes further from the lid margin significantly reduces response amplitudes, highlighting the importance of consistent electrode positioning. However, this does not significantly affect peak times. Thus, it may be feasible to adopt a more comfortable position in participants who cannot tolerate the recommended position if analysis is restricted to peak time parameters